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Participants will visit the laboratory 7 times (baseline and after 1, 2, 3, 4, 5 and 6 months) and will be submitted to clinical and otorhinolaryngological evaluation, sleep questionnaires, polysomnography and blood collection for DNA and extraction and measurement of telomere length, as well as the expression of telomerase and oxidative and inflammatory markers (ADMA, homocysteine, cysteine, TBARS, 8-oxodG, TNF-a, IL-6 and IL-10). We will recruit male participants with OSA diagnosis (apnea-hypopnea indexe15/hour), aged between 35-65 years and body mass index<35 kg/m2, which will be randomized to use CPAP or sham-CPAP for 6 months.
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Pastebot trial length software#
Originally made for software support channels as some users tend to paste errors as plain text instead of using paste services. For this, a randomized, double-blind, sham-controlled clinical study with 6 months duration will be conducted. Discord bot that creates pastebin pastes of long messages. Thus, the aim of this study is to investigate the effect of OSA and its treatment with CPAP on the variation of telomere length and their associated mechanisms. In this sense, the investigators hypothesize that OSA is capable of accelerating aging process through telomere shortening mediated by inflammatory and oxidative markers.
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It is known that cumulative levels of these factors negatively influence the final portion of the DNA, known as telomere. Among the factors associated with its pathophysiology, the role of intermittent hypoxia stands out, contributing to the development of oxidative stress and inflammation. Obstructive sleep apnea (OSA) is a highly prevalent and morbid sleep disorder.
Pastebot trial length free#
It’s free app, and really great if you want to control your Mac via keyboard. I personally use Raycast (an app/URL/everything launcher) that has a clipboard manager included. Save and organize frequently-used clippings into custom pasteboards.
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